BioLean® System

Omega-3 - Clinical trials -
Cardiovascular problems

   Albert, C., H. Campos, et al. (2002)

"Blood Levels of Long-Chain n–3 Fatty Acids and the Risk of Sudden Death." New England Journal of Medicine 346: 1113-1118.


   Burr, M. L., J. F. Gilbert, et al. (1989)

"Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART)." Lancet 2: 757-761.


   Christensen, J. H., M. S. Christensen, et al. (1999)

"Heart rate variability and fatty acid content of blood cell membranes: a dose-response study with n-3 fatty acids." American Journal of Clinical Nutrition 70 : 331-337.


   Christensen, J. H., P. Gustenhoff, et al. (1996)

"Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double-blind randomised controlled trial." British Medical Journal 312 : 677-678.


   de Lorgeril, M., P. Salen, et al. (1999)

"Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study." Circulation 99(6): 779-85.


   de Lorgeril, M., P. Salen, et al. (2002)

"Dietary prevention of sudden cardiac death." European Heart Journal 23(4): 277-85.

   Dolecek, T. A. and G. Granditis (1991)

"Dietary polyunsaturated fatty acids and mortality in the Multiple Risk Factor Intervention Trial (MRFIT)." World Rev Nutr Diet 66: 205-216.

   Durot, I., P. Athias, et al. (1997)

"Influence of phospholipid long chain polyunsaturated fatty acid composition on neonatal rat cardiomyocyte function in physiological conditions and during glucose-free hypoxia-reoxygenation." Molecular & Cellular Biochemistry 175(1-2):253-62.


   Eberhart, C. and R. Dubois (1995)

"Eicosanoids and the gastrointestinal tract . Review." Gastroenterology 109 (1): 285-301.


   Gump BB; MRFIT Research Group (2005)

"Depressive symptoms and mortality in men: results from the Multiple Risk Factor Intervention Trial." Stroke. 2005 Jan;36(1):98-102. Epub 2004 Nov 29.


   Harris JI, Hibbeln JR, Mackey RH, Muldoon MF.

"Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients." Prostaglandins Leukot Essent Fatty Acids


   Hirai, A., T. Terano, et al. (1989)

"Effect of oral administration of highly purified eicosapentaenoic acid and docosahexaenoic acid on platelet function and serum lipids in hyperlipidemic patients." Advances in Prostaglandin, Thromboxane, & Leukotriene Research 19: 627-30.

   Knapp, H. R. (1989)

"Omega-3 fatty acids, endogenous prostaglandins, and blood pressure regulation in humans." Nutrition Reviews 47(10): 301-13.

   Leaf, A. (2002)

"Prevention of fatal cardiac arrhythmias by polyunsaturated fatty acids." Nutrition & Health 16(1): 47-9.

   Lobo, R. A. (2004)

"Evaluation of cardiovascular event rates with hormone therapy in healthy, early postmenopausal women: results from 2 large clinical trials." Archives of Internal Medicine 164(5): 482-4.

   Lu, G., S. L. Windsor, et al. (1999)

"Omega-3 fatty acids alter lipoprotein subfraction distributions and the in vitro conversion of very low density lipoproteins to low density lipoproteins." The Journal of Nutritional Biochemistry 10(3): 151-158.


   Madsen T, et al (2001)

"C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease." Am J Cardiol. 2001 Nov 15;88(10):1139-42.


   Marchioli, R., E. Bomba, et al. (1999)

"Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico."


   Morris, M. C., F. Sacks, et al. (1993)

"Does fish oil lower blood pressure? A meta-analysis of controlled trials.[see comment]." Circulation 88(2): 523-33.


   Nenseter, M. S., A. C. Rustan, et al. (1992)

"Effect of dietary supplementation with n-3 polyunsaturated fatty acids on physical properties and metabolism of low density lipoprotein in humans." Arteriosclerosis & Thrombosis 12(3): 369-79.


   Ridker PM et al (2005)

"C-reactive protein levels and outcomes after statin therapy." N Engl J Med. 2005 Jan 6;352(1):20-8.


   Schrepf R. (2004)

Immediate effects of n-3 fatty acid infusion on the induction of sustained ventricular tachycardia. Schrepf R, Limmert T, Claus Weber P, Theisen K, Sellmayer A. Kardiologie Medizinische Poliklinik, Klinikum der Universitat Munchen, 80336 Munich, Germany.


   Singh, R. B., G. Dubnov, et al. (2002)

"Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial.[see comment]."Lancet 360 (9344): 1455-61.


   Siscovick, D. S., T. E. Raghunathan, et al. (1995)

"Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest." JAMA 274(17): 1363-1367.


   Smith BK, et al (2004)

"Exercise plus n-3 fatty acids: additive effect on postprandial lipemia." Metabolism. 2004 Oct;53(10):1365-71.


   von Schacky, C. and P. C. Weber (1985)

"Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans." Journal of Clinical Investigation 76 (6): 2446-50.


   von Schacky, C., S. Fischer, et al. (1985)

Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. Journal of Clinical Investigation 76(4):1626-31.


   Yusuf S, INTERHEART Study Investigators (2004)

"Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study." Lancet. 2004 Sep 11;364(9438):937-52.


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  • Omega-3 fatty acids for the prevention and treatment of atherosclerotic diseases
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  • Omega-3 fatty acids in the prevention and treatment of cardiovascular disease
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  • Fish Oil Prevents Drop in Heart Rate Variability Due to Indoor Air Pollution
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  • Women catching up on cardiovascular heart disease. Omega-3 important for prevention and treatment.
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  • Cardiovascular Research
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